Preheat the oven to 375℉. Line a 12-cup muffin tin with parchment paper liners or lightly spray each cup with nonstick cooking spray.
In a large bowl, whisk together the biquick mix, Italian seasoning, and garlic powder until evenly combined and no lumps remain.
2 cups Bisquick baking mix, 1 teaspoon Italian seasoning, ½ teaspoon garlic powder
In a separate smaller bowl, whisk together the eggs and milk until combined.
1 cup whole milk, 2 large eggs
Pour the wet ingredients into the bowl of dry ingredients. Stir with a spatula until it is just combined and making sure to not overmix. The batter should be slightly thick but still scoop able.
Stir in the shredded mozzarella cheese until evenly distributed.
1/2 cup shredded mozzarella cheese
Divide the pizza muffin biscuit dough evenly between the muffin cups; filling each cup about 3/4 of the way full.
Bake for 15-18 minutes or until the tops are lightly golden brown and a toothpick inserted into the center comes out clean.
Remove the pan from the oven and immediately spread about 1 tablespoon of pizza on top of each muffin. Sprinkle with some shredded mozzarella cheese, and then top with 4-5 mini pepperonis per muffin.
3/4 cup pizza sauce, 1 cup shredded mozzarella cheese, mini pepperonis
Return the muffin pan to the oven and cook for an additional 2-3 minutes just until the cheese is melted and bubbly.
Cool the muffins in the warm pan for 5 minutes before removing them for serving. Serve warm with a side of warm pizza sauce for dipping. Enjoy!